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A Disease is any type of sickness which can come over a users Neopet. Pets do not simply recover from a disease with time, instead, each disease has its own unique cure, a certain item that must be used on your pet in order to cure it. While sick a Neopet will continue to lose hit points, be unable to fight in the battledome, and become more misreble until it's cured. They can be diagnosed at the NeoHospital, and the cures can be bought at Neopian Pharmacy or other such stores. A disease can also be cured at the Healing Springs in Faerieland, but may several visits as all effects of the Healing Springs are random.
Diseases can occur as Random Events, or may be triggered by an item such as Rotten Omelette. Chance-based areas of the website can also affect a users Neopet, such as the Wheel of Excitement which features a different Disease your Neopet can be afflicted with every few months. Also, some weapons of the battledome have been known to cause sickness, as have 1-Player Challengers.