Since someone asked in another topic, here are my tips for getting, well, any score you want. To get 142,000 points, I just did a few simple things.
First, as soon as the game started I entered the pyramibread cheat. That will list on the screen an available combo. Then I'd basically just look for combos. If I didn't see one instantly (very important) I'd click control and the combo cheat would occur again.
As long as you can find a combo right after the last one is clicked, you should be fine. What used to kill me was the delay in looking instead of using the cheat. That's basically the key, just remembering to use pyramibread instantly, because it itself has a little delay. You can also use the cheat that gives you more time, but you shouldn't need it at all if you get into the groove and find tiles quickly. Using the cheat too much can hurt you too. It's always faster to find combos yourself. If you only rely on the cheat to find them, I think you may run out of time.
Oh, each time the board shuffles, it pauses. Try to take breaks when this happens instead of wasting game pauses. Also, when you're ready to play after a shuffle, look at the board before you click. Though some of the board is covered, you can still make out some tiles below the grey.
Hope this helps