From their trouble shooting guide.
I cannot open Mozilla / my profile. Mozilla says the profile is in use.
Look in your profile directory for file called parent.lock, lock, or .parentlock. Delete the file. (The file is created on start-up to prevent multiple instances of Mozilla or Mozilla-based browser from accessing the same profile simultaneously. The file is destroyed on exit.)
and how to locate the directory.
Where is my profile stored?
The location of a profile has three elements: the BASE, its NAME, and its SALT (xxxxxxxx.slt). For example,
C:\Windows\Application Data\Mozilla\Profiles\ John Smith\ lm34qgkq.slt
base profile directory name salt
The BASE profile directory houses the profile registry (Registry.dat) file. The BASE directory depends on the system settings, as will be described later.
When you create a new profile, you can choose a different BASE directory and NAME sub-directory to put your profile files.
The SALT is a sub-directory named with eight random alpha-numerals followed by .slt extension (see 7.4 What is the @$%#@$%#.slt directory in my profile directory?). When you create a new profile, Mozilla automatically generates a SALT directory if it doesn't already exist. But if SALT does exist, the Profile Manager will use it.
The following lists typical base profile directories:
Windows
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On Windows 95, Windows 98, or Windows ME (without log-in), a typical base profile location is:
C:\Windows\Application Data\Mozilla\Profiles\
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On Windows 95, Windows 98 or Windows ME with login, a typical base profile location is:
C:\Windows\Profiles\[Log-in Name]\Application Data\Mozilla\Profiles\
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On Windows 2000 or Windows XP, a typical base profile location is:
C:\Documents and Settings\[Log-in Name]\Application Data\Mozilla\Profiles\
Note: on Windows 2000 and Windows XP, the Document and Settings directory is hidden twice; to access the directory, you may need to set Windows Explorer to show System and Hidden directories and files.
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